neuromodulation lab Baylor College of Medicine 713-798-4696

Baylor College of Medicine · Neurosurgery

Deep brain stimulation

Deep brain stimulation (DBS) is a surgical treatment for Parkinson's disease, essential tremor, dystonia, and obsessive compulsive disorder. It does not cure these conditions. For carefully selected patients, it can substantially reduce symptoms for many years. This page explains how DBS works, who it helps and who it does not, what the process involves, and how to be evaluated by the program at Baylor College of Medicine.

Appointments Monday through Friday, 8 a.m. to 5 p.m. · Surgery performed at Baylor St. Luke's Medical Center in the Texas Medical Center, Houston

1,000+
DBS devices implanted with the Parkinson's Disease Center and Movement Disorders Clinic since the 1990s
300+
patients with DBS actively followed in our program today
First in Texas
to perform image-guided and "asleep" DBS
First in the region
in the South Central U.S. to offer DBS for OCD and treatment-resistant depression

How It Works

What is deep brain stimulation?

Deep brain stimulation works something like a pacemaker for the brain. A thin electrode is placed in a precisely chosen area deep in the brain, where movement or mood circuits have become overactive or disorganized. A small battery-powered device under the skin of the chest delivers gentle electrical pulses that quiet the abnormal signaling.

Unlike procedures that permanently remove or lesion tissue, stimulation is adjustable and reversible. Your care team tunes the settings to your symptoms over time, and the system can be turned off or removed. More than 250,000 people worldwide live with a DBS system today.

Our neurosurgeons also study these brain circuits directly. That research, on how the brain's signals differ from patient to patient, is aimed at one goal: making stimulation personal, so the therapy fits your symptoms rather than an average patient's.

Lead Electrode in the brain Target Deep brain region Extension Wire under the skin Pulse generator Battery below the collarbone
A DBS system has three parts, all under the skin: the lead, the extension, and the pulse generator.
  • Leada wire thinner than a strand of spaghetti, placed in the brain target
  • Extensiona connecting wire that runs behind the ear and down the neck
  • Pulse generatorthe "pacemaker," placed below the collarbone; rechargeable or non-rechargeable

Conditions We Treat

Conditions treated with DBS

DBS is an established treatment for the movement disorders below and for severe obsessive compulsive disorder. Each condition has its own brain target, its own evidence base, and its own realistic expectations.

Movement Disorders

Parkinson's disease

For people whose medications still work but no longer last, DBS can extend your best "on" time through most of the day and smooth out fluctuations and dyskinesia. Most patients also reduce their medication doses.

Movement Disorders

Essential tremor

When tremor keeps you from writing, eating, or working despite medication, thalamic DBS improves tremor substantially in the large majority of well-selected patients. Incisionless focused ultrasound is an alternative for some.

Movement Disorders

Dystonia

DBS is an established therapy for generalized, segmental, and cervical dystonia that has not responded to medications and botulinum toxin. Benefit often builds gradually over months.

Movement Disorders

Tourette syndrome

For severe, medication-refractory tics in carefully selected adults, DBS can be considered by our multidisciplinary team on a case-by-case basis.

Psychiatric

Obsessive compulsive disorder

Working with the Menninger Department of Psychiatry, we were the first center in the South Central U.S. to offer DBS for severe, treatment-resistant OCD, an FDA-approved use under a humanitarian device exemption.

Psychiatric · Research

Treatment-resistant depression

DBS for depression is investigational. Our program runs some of the nation's leading clinical trials, and eligible patients may be able to enroll. See research and trials.

Already have a DBS system?

The program evaluates patients whose DBS was implanted elsewhere for second opinions, reprogramming, troubleshooting, battery replacement, and revision surgery. An underperforming system usually has a correctable cause. Call 713-798-4696 and ask for a DBS second opinion.

Candidacy

Who is a candidate

DBS is not a last resort, and it is not appropriate for everyone. It is usually considered when medications still help but no longer last through the day. Two principles guide candidacy:

1. Your best "on" is the ceiling. For Parkinson's disease, the symptoms that improve when your levodopa is working at its best are the symptoms most likely to improve with DBS. Think of DBS as making your best hours last most of the day. When medications have stopped working completely, DBS will not work either.

2. DBS treats symptoms, not the disease. It does not slow or stop the underlying condition, and it will not relieve every symptom.

What DBS typically helps

  • Tremor, in Parkinson's disease and essential tremor
  • Stiffness and slowness that respond to levodopa
  • Medication "off" time and wearing-off fluctuations
  • Dyskinesia (involuntary movements from medication)
  • Dystonic postures and movements
  • Severe OCD symptoms, in the approved setting

What DBS usually does not help

  • Balance problems and falls
  • Freezing of gait that occurs during your best "on" time
  • Speech and swallowing difficulty (these can worsen)
  • Memory and thinking problems
  • Apathy, anxiety, or depression in Parkinson's disease
  • Symptoms that never respond to your medications

When to consider an evaluation

  • Your diagnosis of Parkinson's disease, essential tremor, or dystonia is well established, and symptoms interfere with daily life despite good medical therapy
  • For Parkinson's: levodopa clearly helps, but doses wear off, or dyskinesia limits how much you can take
  • For tremor: medications such as propranolol or primidone have been tried without enough benefit
  • Your thinking and memory are largely intact, and your mood is stable or well managed
  • You have family or friends who can support you through surgery and programming visits

An evaluation does not commit you to surgery. Many evaluations conclude that DBS is not the right option at this time, and that is a useful result.

What to Expect

The evaluation and treatment process

From first visit to optimized stimulation typically takes several months. The steps are the same for every patient.

  1. Weeks 1 to 4

    Referral and first visit

    You or your physician calls 713-798-4696, or your neurologist sends records. You will be seen by a fellowship-trained movement disorders neurologist or functional neurosurgeon, who reviews your history, confirms the diagnosis, and makes sure medical therapy has been optimized first.

  2. Next 4 to 8 weeks

    Multidisciplinary evaluation

    A structured workup: a motor exam on and off medication when relevant, detailed neuropsychological testing of memory and thinking, brain MRI, and psychiatric evaluation when appropriate. Each component either confirms that DBS is likely to help or identifies a reason it is not.

  3. Team Conference

    Case conference and recommendation

    Neurosurgery, neurology, neuropsychology, and psychiatry review your evaluation together and reach a consensus: proceed with DBS, optimize something first, or recommend an alternative such as focused ultrasound or continued medical therapy. We call you with the recommendation and the reasoning behind it.

  4. Surgery Day

    Lead placement

    The electrode is placed through a small opening in the skull using precise image guidance, either awake with brain-cell recording to confirm the target, or asleep under general anesthesia with intraoperative imaging. Placement is verified before you leave the operating room. Most patients stay one night.

  5. 1 to 2 weeks later

    Pulse generator placement

    A short outpatient procedure under general anesthesia connects the lead to the pacemaker-like generator below your collarbone. You go home the same day.

  6. Months 1 to 6

    Programming and optimization

    A few weeks after surgery, once healing settles, stimulation is switched on. Finding your best settings takes several visits over three to six months, and benefit can continue to build for up to a year. Medications are adjusted alongside. After that, you return for periodic checks, and the program follows you for the life of the device.

Surgical Options

Surgical options: awake and asleep DBS

The program was the first in Texas to perform image-guided "asleep" DBS and also performs awake surgery with microelectrode recording. Both approaches are accurate in experienced hands. The choice depends on the condition, the anatomy, and patient preference.

Awake DBS with brain recordingAsleep, image-guided DBS
How it works Under light sedation, microelectrodes "listen" to individual brain cells to map the target, and test stimulation confirms benefit and checks for side effects in real time. The brain itself has no pain receptors. Under general anesthesia, the lead is placed using high-resolution imaging (intraoperative CT or MRI) that verifies the target during the procedure. No need to be awake at any point.
Best suited for Patients whose target benefits from live physiologic confirmation, and those who want their symptom response tested on the table. Patients with significant anxiety about awake surgery, severe "off" symptoms that make awake surgery hard, or anatomy well defined on imaging.
What patients notice You are comfortable and conversing during mapping; some pressure and sounds, no pain in the brain. You go to sleep, you wake up with the lead placed.

Frameless and frame-based techniques. We offer both traditional stereotactic frames and "frameless" systems, choosing the platform that gives the most accurate trajectory for your target.

An incisionless alternative: MR-guided focused ultrasound. For essential tremor and tremor-dominant Parkinson's disease, we also offer focused ultrasound, which treats tremor with no incision and no implant. It is a genuine alternative with real tradeoffs: it creates a small permanent lesion rather than adjustable stimulation, and it is not reversible. Because the program offers both, the recommendation is based on which treatment fits the patient. Learn about focused ultrasound at Baylor Medicine.

When stimulation is not the right tool. For selected patients we also offer stereotactic lesioning procedures (thalamotomy, pallidotomy, capsulotomy), stereotactic radiosurgery, and laser interstitial thermal therapy.

Safety

Risks and realistic expectations

DBS is brain surgery. Its risks fall into three categories, which differ in seriousness and in how readily they can be corrected.

Surgical risks

≈1%

The most serious risk, bleeding in the brain (which can include stroke), occurs in about 1 percent of procedures. Infection occurs in roughly 1 to 3 percent and sometimes requires antibiotics or temporary removal of hardware. We review your individual risk profile with you before any decision.

Stimulation side effects

Adjustable

Tingling, speech changes, or balance changes can occur when stimulation is on. These are usually improved or eliminated by adjusting the settings, which is the core advantage of stimulation over a permanent lesion.

Hardware issues

Fixable

Wires can rarely break or move, and batteries need replacement (roughly every 3 to 5 years, or about 15 years for rechargeable systems). When a DBS system underperforms, the cause is usually identifiable and correctable.

DBS does not make patients symptom-free, and the underlying condition continues on its own course. For well-selected patients, it reliably reduces symptoms for years. The purpose of the evaluation is to determine, before surgery, whether that benefit is likely for you.

Our Team

Our team

Every patient is evaluated and followed by specialists in neurosurgery, neurology, psychiatry, and neuropsychology, who review each case together.

Functional Neurosurgery

Ashwin Viswanathan, MDProfessor and Director of Functional Neurosurgery. First surgeon in Texas to perform image-guided and asleep DBS. Fellowship trained in stereotactic and functional neurosurgery.
Sameer A. Sheth, MD, PhDProfessor and Vice Chair of Research, Cullen Foundation Endowed Chair. Leads the program's psychiatric DBS and adaptive stimulation research.

Movement Disorders Neurology · Parkinson's Disease Center and Movement Disorders Clinic

Joseph Jankovic, MDProfessor of Neurology, Distinguished Chair in Movement Disorders. Founder and director of the Parkinson's Disease Center and Movement Disorders Clinic.
Arjun Tarakad, MDMovement disorders neurologist. Director of the center's DBS program.
Nora Vanegas Arroyave, MDMovement disorders neurologist with expertise in DBS candidacy and programming.
Steven Bellows, MDMovement disorders neurologist, DBS trained. Director of the Movement Disorders Fellowship.

Psychiatry · Menninger Department of Psychiatry and Behavioral Sciences

Wayne Goodman, MDProfessor and Chair. Developer of the Yale-Brown Obsessive Compulsive Scale; co-leads the OCD and depression DBS programs.

Neuropsychology

Michele York, PhD, ABPP-CNProfessor of Neurology. Cognitive evaluation for DBS candidacy and outcomes.
Adriana Strutt, PhD, ABPP-CNBoard-certified clinical neuropsychologist.
Hannah Combs, PhD, ABPP-CNBoard-certified clinical neuropsychologist.

Research

Research and clinical trials

The program's NIH-funded laboratory records and analyzes the brain's electrical activity to make stimulation more precise and more individual. Patients treated here may be eligible for clinical trials.

Personalizing DBS for Parkinson's disease. Not all Parkinson's is the same. With NIH support (R01 NS124650), our lab studies how the brain's electrical signatures differ between tremor-dominant Parkinson's and the gait-and-balance-dominant form, so that stimulation can be tailored to the symptoms each patient actually has, including with newer directional leads and devices that sense brain activity.

Telkes I, Viswanathan A, Jimenez-Shahed J, et al. Local field potentials of subthalamic nucleus contain electrophysiological footprints of motor subtypes of Parkinson's disease. Proceedings of the National Academy of Sciences. 2018;115(36):E8567-E8576.

Advancing DBS for psychiatric conditions. Our investigators helped discover the first neural biomarker of OCD symptom state, published in Nature Medicine, work that points toward devices that adjust themselves to the patient's needs.

Selected trials currently enrolling

  • NCT03437928Deep brain stimulation for treatment-resistant depression
  • NCT06423430TRANSCEND: subcallosal cingulate network DBS for treatment-resistant depression
  • NCT06599099DBS for treatment-resistant bipolar depression

Interested in a trial? Mention it when you call, or ask your physician to note it in the referral.

Referrals

For referring physicians

Referred patients return to their referring physician for ongoing neurological and primary care, with clinic notes and programming updates. Questions before a formal referral are welcome by phone or email.

How to refer

What to send with the referral

  • Demographics and insurance information
  • Clinic notes documenting diagnosis and treatment course
  • Current medication list; for Parkinson's, the levodopa response history
  • Recent brain MRI if available (or upload via Ambra)
  • Any prior neuropsychological testing

Incomplete records should not delay a referral; send what you have and we will take it from there.

FAQ

Frequently asked questions

Am I a candidate for DBS, and when is the right time to consider it?

The best candidates have a clear diagnosis, disabling symptoms despite good medical therapy, intact thinking, and stable mood. For Parkinson's disease, a strong response to levodopa is the single best predictor of benefit. DBS is not a last resort: waiting until medications have stopped working entirely usually means waiting too long. If you are asking the question, an evaluation is reasonable; "not yet" is a common and useful answer.

Will DBS cure my condition or stop it from getting worse?

No. DBS treats symptoms. It does not slow or stop the underlying disease, which continues its own course. What it can do is give back a large portion of each day for years, and its settings can be adjusted as your condition changes.

Which symptoms will improve, and which will not?

For Parkinson's disease: tremor, stiffness, slowness, medication fluctuations, and dyskinesia typically improve. Balance, freezing of gait during "on" time, speech, memory, and mood usually do not, and speech or balance can occasionally worsen. For essential tremor, the target symptom is tremor itself. We will give you a personalized version of this list at your evaluation, in writing.

What are the risks?

Three kinds. Surgical: about a 1 percent risk of bleeding in the brain (which can include stroke) and roughly 1 to 3 percent risk of infection. Stimulation-related: tingling, speech or balance changes that can usually be programmed away. Hardware-related: battery replacement on schedule and rare wire problems, which are fixable. We will review your individual risks in detail before any decision.

Do I have to be awake for brain surgery?

Not necessarily. We offer both awake surgery with brain-cell recording and fully asleep, image-guided surgery, and we were the first program in Texas to perform the asleep approach. Both are accurate in experienced hands; the choice depends on your condition, anatomy, and preference. Patients who are awake feel pressure and hear sounds but no pain, because the brain has no pain receptors.

What does the surgery actually involve, and how long is recovery?

Two stages. First, lead placement through a small opening in the skull, usually with one overnight stay. One to two weeks later, a short outpatient procedure places the pulse generator below the collarbone. Most people take it easy for about two weeks and avoid strenuous activity for four to six weeks. Stimulation is switched on a few weeks after surgery.

Will my medications change after DBS?

Usually reduced, rarely eliminated. Most Parkinson's patients take meaningfully less medication after DBS, which itself reduces side effects like dyskinesia. Plan on adjustments across the programming period rather than a single change.

How soon will I feel better, and what is "programming"?

Programming is the process of tuning your stimulation settings, and it is where much of the benefit is won. First programming happens a few weeks after surgery. Finding your best settings typically takes several visits over three to six months, and benefit can continue to build for up to a year. Tremor often responds quickly; dystonia improves more gradually.

How is DBS different from focused ultrasound, and how do I choose?

Focused ultrasound treats tremor by creating a small permanent lesion with no incision and no implanted device: one procedure, no hardware, but not adjustable and not reversible. DBS requires surgery and a device, but it is adjustable, reversible, and treatable on both sides of the body. We offer both, so the recommendation you get is based on your situation, not on program capability.

Will DBS change my thinking, speech, or personality?

This is exactly why every candidate has neuropsychological testing before surgery. DBS does not typically change who you are. Speech can be affected in some patients, and people with significant memory problems before surgery are at higher risk of worsening, which is one reason testing can lead to a "no" that protects you.

What is life with the device like? MRI scans, airports, exercise?

Largely normal. Modern DBS systems are MRI-conditional, meaning scans can be done under specific settings, and we coordinate that when needed. Airport security is fine: you carry a device ID card and request a hand search or walk through with precautions per the manufacturer. Most sports and exercise are fine once healed; we will go over the short list of things to avoid.

What about the battery?

Non-rechargeable batteries last roughly 3 to 5 years depending on your settings and are replaced in a short outpatient procedure. Rechargeable systems last about 15 years and require regular recharging at home. We check battery status at every visit; running out unexpectedly is avoidable and symptoms return if stimulation stops, so we schedule replacements ahead of time.

Does insurance cover DBS?

Medicare and most private insurers cover DBS for its approved indications, including Parkinson's disease, essential tremor, dystonia, and OCD. Prior authorization is typically required, and our team handles that process with you.

What if DBS does not work for me?

First, we find out why. Underperforming DBS usually has an identifiable cause: settings that need reprogramming, medication interactions, a lead that is not in the ideal spot, or expectations that were set on the wrong symptoms. Most causes are correctable, and we run this troubleshooting for patients implanted here and elsewhere. Having DBS also does not disqualify you from future therapies.

Appointments and Locations

Appointments

Call 713-798-4696, Monday through Friday, 8 a.m. to 5 p.m. A referral is not required, and a completed workup is not needed before the first visit.

Clinic

Baylor Medicine, McNair Campus
7200 Cambridge Street, 9th Floor
Houston, TX 77030

Phone: 713-798-4696
Online: Request an appointment · MyChart

Surgery

Baylor St. Luke's Medical Center
Texas Medical Center
Houston, TX

DBS procedures are performed at Baylor St. Luke's, where our surgeons lead the neurosurgery service. Patients traveling from out of town should mention it when calling; visits can often be consolidated.